Cytopoint is the name of a caninized monoclonal antibody produced using Chinese hamster ovary cells (CHO).
This medication comes in the form of an injectable solution. The drug should be transparent and opalescent in appearance and should not contain visible particles.
This medicine is used for dogs. It is used to treat itching due to allergic dermatitis in dogs and to treat the clinical signs of atopic dermatitis.
This medicine should not be used in dogs that are sensitive to the active ingredient or ingredients. It should also not be used on dogs weighing less than 3 kg.
Cytopoint may cause temporary or permanent production of antibodies to the drug in some animals. This condition is rare and these antibodies may have no effect on treatment (transient antibodies). Or it may reduce treatment effectiveness in animals that have previously responded to treatment (persistent antibodies).
Special Precautions For Cytopoint Use
Prevention or elimination of the allergen is important for successful treatment of allergic dermatitis. When treating itching due to allergic dermatitis with Cytopoint, underlying causes must be investigated and treated (e.g., flea allergic dermatitis, contact dermatitis, food allergy).
This medication is not used as long-term maintenance therapy if successful allergen elimination or prevention is possible. Additionally, in cases of allergic dermatitis and atopic dermatitis, it is recommended to investigate and treat factors that lead to complications such as infections and parasite infestations (e.g. fleas, scabies).
It is particularly recommended that dogs be monitored during the first weeks of treatment to detect bacterial infections associated with dermatitis.
If there is no response or the response is limited one month after the first dose is given, a second dose should be given. If there is no improvement in the animal’s response one month after the second dose, the veterinarian should consider alternative treatments.
Special Precautions The Veterinarian Should Take
In case of accidental self-injection, reactions including hypersensitivity reactions, even anaphylaxis may occur. Accidental self-injection may produce an immune response to Cytopoint. This usually does not cause adverse effects, but repeated accidental injections may increase the risk of hypersensitivity reactions. In case of accidental self-injection, you should immediately consult a doctor and show the package insert or label.
What Side Effects Does Cytopoint Cause?
It has been reported that hypersensitivity reactions such as anaphylaxis, facial edema, and urticaria occur in rare cases. In these cases, appropriate treatment should be applied immediately.
Reports have indicated that vomiting and/or diarrhea have occurred in rare cases and these effects may be associated with hypersensitivity reactions. If necessary, treatment should be applied.
From reports, in rare cases, neurological signs (seizures, convulsions or ataxia) have been observed after the use of this veterinary drug.
In very rare cases, changes such as pain or swelling at the application site have been reported.
In very rare cases, clinical manifestations associated with immune-mediated diseases (such as hemolytic anemia or thrombocytopenia) have been reported.
The safety of this medicine during pregnancy and breastfeeding has not been proven. Therefore, its use is not recommended during pregnancy, breastfeeding or reproductive periods.
If another vaccine is given during Cytopoint treatment, it is recommended that the vaccine be administered to a different site.
Dosage And Route Of Administration
It is administered subcutaneously. Avoid excessive agitation of the solution or formation of foam. The entire ampoule (1 ml) should be applied. The dose should be adjusted according to the dosage table below.
For dogs weighing more than 40 kg, the contents of more than one ampoule are required to give a single dose. In this case, you should draw the appropriate amount of each ampoule into the same syringe. You should gently invert the syringe 3 or 4 times before injection to mix the solution.
Dosage and treatment plan
The minimum recommended dose is 1 mg per kilogram. It should be given once every month. The need to repeat or extend treatment in dogs with allergic dermatitis should be determined for each patient by the responsible veterinarian, who evaluates the ability to remove or avoid the allergenic stimulus.
Cytopoint Dosing Chart
Dosage should be applied according to the following dosage table:
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